Thursday, November 20, 2014
"In July of 2011, a German research group revisited the question of converting fatty acids to carbohydrate by publishing a computational analysis of the most up-to-date information about human biochemistry available (9). These authors identified 22 pathways by which acetone could be converted to pyruvate that they considered likely to be important, and concluded that these pathways would be less cost-efficient than making glucose from amino acids or glycerol, but are nevertheless biochemically feasible and likely serve as supplementary modes of glucose production. "
See Chris Masterjohns full article here -
"Gluconeogenesis is a ubiquitous process, present in plants, animals, fungi, bacteria, and other microorganisms. In vertebrates, gluconeogenesis takes place mainly in the liver and, to a lesser extent, in the cortex of kidneys. In ruminants, this tends to be a continuous process. In many other animals, the process occurs during periods of fasting, starvation, low-carbohydrate diets, or intense exercise. The process is highly endergonic until it is coupled to the hydrolysis of ATP or GTP, effectively making the process exergonic. For example, the pathway leading from pyruvate to glucose-6-phosphate requires 4 molecules of ATP and 2 molecules of GTP to proceed spontaneously. Gluconeogenesis is often associated with ketosis. Gluconeogenesis is also a target of therapy for type II diabetes, such as metformin, which inhibits glucose formation and stimulates glucose uptake by cells. In ruminants, because metabolizable dietary carbohydrates tend to be metabolized by rumen organisms, gluconeogenesis occurs regardless of fasting, low-carbohydrate diets, exercise, etc."