Health A-Z

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What Is It?

Immune thrombocytopenic purpura (ITP), also known by the shorter name Immune Thrombocytopenia (same abbreviation ITP), can be understood by looking at the three terms that make up its name:

  • Immune indicates that the illness is caused by the immune system, which makes cells and antibodies that attack the person's own platelets the parts of the blood that help the blood to clot.

  • Thrombocytopenic means that the illness is related to low levels of thrombocytes, another name for platelets. Platelets are produced in the bone marrow (the central lining of the bones). The body needs adequate numbers of functioning platelets to allow blood to clot and to limit bleeding if you are cut or experience other types of trauma.

  • Purpura means that the illness produces a red or purple rash that is caused by bleeding under the skin. This is only one manifestation of the disease

In short, ITP is an illness in which unusually low levels of platelets lead to purpura and other forms of abnormal bleeding.

In people with ITP, the immune system produces abnormal proteins called antiplatelet antibodies. These misdirected proteins attach themselves to the surface of blood platelets as if the platelets were "foreign" or invading bacteria or viruses. As the affected platelets circulate in the bloodstream, they are recognized as abnormal by the spleen and removed from the blood.

As more and more platelets are removed by the spleen, the level of platelets in the blood drops past the lower limit of normal (about 130,000 per cubic millimeter of blood) and the patient is diagnosed with thrombocytopenia (low platelet count).

When platelet levels fall into the 30,000 to 50,000 range, a person may begin to have abnormal bleeding after a minor skin injury, such as a small cut, bruise, medical injection, blood test or tooth extraction.

If platelet levels fall below 10,000, the person has an increased risk of bleeding even when no injury has occurred. This type of bleeding is especially dangerous if it happens inside the skull and brain, where it is known as an intracranial hemorrhage. Bleeding may also occur in the kidneys and bladder causing bloody urine. Excessive bleeding can also occur during normal menstrual cycles.

There are currently three classifications of ITP:

  • Newly diagnosed (also referred to as acute) ITP This form of ITP lasts for less than three months and typically affects children, most commonly those between the ages of 2 and 6. It usually appears shortly after a viral infection. Most children with acute ITP recover without treatment, and their platelet counts eventually rise to normal levels. However, 7% to 28% of people with newly diagnosed ITP can go on to develop either persistent or chronic ITP.

  • Persistent ITP: Here, the disease has been present for 3 to 12 months, and has not undergone spontaneous correction or remission on its own. It still is persistent in the face of several trials of treatment.

  • Chronic ITP This form of ITP lasts for more than 12 months, usually strikes adults between the ages of 20 and 40, and requires medical treatment to restore normal platelet levels. Chronic ITP is three times more common in women than men. Typically, a person has weeks or months of mild to moderate abnormal bleeding off and on before seeing a doctor.

In most cases, the cause of ITP is unknown. In a few cases, ITP can be a reaction to a specific drug or food ingredient, such as quinine in tonic water. In the United States, ITP is a relatively rare illness that affects about four out of every 100,000 people each year

ITP can occur during pregnancy. The low platelets can lead to serious bleeding problems both in the mother and fetus.

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From Health A-Z, Harvard Health Publications. Copyright 2007 by the President and Fellows of Harvard College. All rights reserved. Written permission is required to reproduce, in any manner, in whole or in part, the material contained herein. To make a reprint request, contact Harvard Health Publications. Used with permission of StayWell.

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